The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism

The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism

Abstract Inhibition of the mitochondrial metabolism offers a promising therapeutic approach for the treatment of cancer. Here, we identify the mycotoxin viriditoxin (VDT), derived from the endophytic fungus Cladosporium cladosporioides, as an interesting candidate for leukemia and lymphoma treatment...

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Bibliographic Details
Main Authors: Fabian Stuhldreier, Laura Schmitt, Thomas Lenz, Ilka Hinxlage, Marcel Zimmermann, Philipp Wollnitzke, Julian Schliehe-Diecks, Yang Liu, Paul Jäger, Stefanie Geyh, Nicole Teusch, Christoph Peter, Sanil Bhatia, Rainer Haas, Bodo Levkau, Andreas S. Reichert, Kai Stühler, Peter Proksch, Björn Stork, Sebastian Wesselborg
Format: Article
Language:English
Published: Nature Publishing Group 2022-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05356-w

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https://doi.org/10.1038/s41419-022-05356-w

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