Simultaneous quantitation of 17 endogenous adrenal corticosteroid hormones in human plasma by UHPLC-MS/MS and their application in congenital adrenal hyperplasia screening

Simultaneous quantitation of 17 endogenous adrenal corticosteroid hormones in human plasma by UHPLC-MS/MS and their application in congenital adrenal hyperplasia screening

Accurate investigation of adrenal hormone levels plays a vital role in pediatric endocrinology for the detection of steroid-related disorders. This study aims to develop a straightforward, sensitive UHPLC-MS/MS method to quantify 17 endogenous adrenal corticosteroid hormones in human plasma. These h...

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Bibliographic Details
Main Authors: Qiaoxuan Zhang, Min Zhan, Huihui Wu, Pinning Feng, Xing Jin, Zemin Wan, Jun Yan, Pengwei Zhang, Peifeng Ke, Junhua Zhuang, Jiuyao Zhou, Liqiao Han, Xianzhang Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Chemistry
Subjects:
UHPLC-MS/MS
adrenal hormones
simultaneous quantitation
congenital adrenal hyperplasia
diagnostic efficiency
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.961660/full

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https://www.frontiersin.org/articles/10.3389/fchem.2022.961660/full

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