Mesenchymal stem cell-derived exosomes ameliorate cardiomyocyte apoptosis in hypoxic conditions through microRNA144 by targeting the PTEN/AKT pathway

Mesenchymal stem cell-derived exosomes ameliorate cardiomyocyte apoptosis in hypoxic conditions through microRNA144 by targeting the PTEN/AKT pathway

Abstract Background A growing body of evidence suggests that stem cell-derived exosomal microRNAs (miRNAs) could be a promising cardioprotective therapy in the context of hypoxic conditions. The present study aims to explore how miRNA-144 (miR-144), a miRNA contained in bone marrow mesenchymal stem...

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Bibliographic Details
Main Authors: Zhuzhi Wen, Zun Mai, Xiaolin Zhu, Tao Wu, Yangxin Chen, Dengfeng Geng, Jingfeng Wang
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Exosomes
microRNA-144
PTEN/AKT pathway
Cell apoptosis
Online Access:https://doi.org/10.1186/s13287-020-1563-8

Internet

https://doi.org/10.1186/s13287-020-1563-8

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