Newly Developed Recombinant Antithrombin Protects the Endothelial Glycocalyx in an Endotoxin-Induced Rat Model of Sepsis

Newly Developed Recombinant Antithrombin Protects the Endothelial Glycocalyx in an Endotoxin-Induced Rat Model of Sepsis

(1) Background: The endothelial glycocalyx is a primary target during the early phase of sepsis. We previously reported a newly developed recombinant non-fucosylated antithrombin has protective effects in vitro. We further evaluated the effects of this recombinant antithrombin on the glycocalyx dama...

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Bibliographic Details
Main Authors: Toshiaki Iba, Jerrold H. Levy, Koichiro Aihara, Katsuhiko Kadota, Hiroshi Tanaka, Koichi Sato, Isao Nagaoka
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
antithrombin
endothelium
glycocalyx
syndecan-1
hyaluronan
Online Access:https://www.mdpi.com/1422-0067/22/1/176

Internet

https://www.mdpi.com/1422-0067/22/1/176

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