A GSH/CB Dual-Controlled Self-Assembled Nanomedicine for High-Efficacy Doxorubicin-Resistant Breast Cancer Therapy

A GSH/CB Dual-Controlled Self-Assembled Nanomedicine for High-Efficacy Doxorubicin-Resistant Breast Cancer Therapy

Chemoresistance is a major therapeutic obstacle in the treatment of breast cancer. Therefore, how to overcome chemoresistance is a problem to be solved. Here, a glutathione (GSH)/cathepsin B (CB) dual-controlled nanomedicine formed by cyclic disulfide-bridged peptide (cyclic-1a) as a potent anticanc...

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Bibliographic Details
Main Authors: Yang Yang, Quanfeng Zhao, Zhe Peng, Yunjiang Zhou, Miao-Miao Niu, Lin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
cyclic peptide
GSH
cathepsin B
drug-resistance
breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.811724/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.811724/full

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