CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory

CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory

Although the role of CCR5 in immunity and in HIV infection has been studied widely, its role in neuronal plasticity, learning and memory is not understood. Here, we report that decreasing the function of CCR5 increases MAPK/CREB signaling, long-term potentiation (LTP), and hippocampus-dependent memo...

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Bibliographic Details
Main Authors: Miou Zhou, Stuart Greenhill, Shan Huang, Tawnie K Silva, Yoshitake Sano, Shumin Wu, Ying Cai, Yoshiko Nagaoka, Megha Sehgal, Denise J Cai, Yong-Seok Lee, Kevin Fox, Alcino J Silva
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
CCR5
hippocampus
barrel cortex
learning and memory
HIV-associated cognitive deficits
gp120
Online Access:https://elifesciences.org/articles/20985

Internet

https://elifesciences.org/articles/20985

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