CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory
Although the role of CCR5 in immunity and in HIV infection has been studied widely, its role in neuronal plasticity, learning and memory is not understood. Here, we report that decreasing the function of CCR5 increases MAPK/CREB signaling, long-term potentiation (LTP), and hippocampus-dependent memo...
Main Authors: | Miou Zhou, Stuart Greenhill, Shan Huang, Tawnie K Silva, Yoshitake Sano, Shumin Wu, Ying Cai, Yoshiko Nagaoka, Megha Sehgal, Denise J Cai, Yong-Seok Lee, Kevin Fox, Alcino J Silva |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-12-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/20985 |
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