Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment.

Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment.

Statins are widely prescribed for reducing LDL-cholesterol (C) and risk for cardiovascular disease (CVD), but there is considerable variation in therapeutic response. We used a gas chromatography-time-of-flight mass-spectrometry-based metabolomics platform to evaluate global effects of simvastatin o...

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Bibliographic Details
Main Authors: Miles Trupp, Hongjie Zhu, William R Wikoff, Rebecca A Baillie, Zhao-Bang Zeng, Peter D Karp, Oliver Fiehn, Ronald M Krauss, Rima Kaddurah-Daouk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3392268?pdf=render

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http://europepmc.org/articles/PMC3392268?pdf=render

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