Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice

Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice

Cardiac myocytes from the mdx mouse, the mouse model of Duchenne muscular dystrophy, exhibit t-tubule disarray and increased calcium sparks, but a unifying molecular mechanism has not been elucidated. Recently, improper trafficking of junctophilin (JPH)-2 on an altered microtubule network caused t-t...

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Bibliographic Details
Main Authors: Kurt W. Prins, MD, PhD, Michelle L. Asp, PhD, Huiliang Zhang, PhD, Wang Wang, MD, PhD, Joseph M. Metzger, PhD
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:JACC: Basic to Translational Science
Subjects:
calcium handling
Duchenne cardiomyopathy
junctophilin-2
microtubules
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16000371

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http://www.sciencedirect.com/science/article/pii/S2452302X16000371

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