Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

Abstract Background The accumulation of amyloid beta (Aβ) peptides in fibrils is prerequisite for Alzheimer’s disease (AD). Our understanding of the proteins that promote Aβ fibril formation and mediate neurotoxicity has been limited due to technical challenges in isolating pure amyloid fibrils from...

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Bibliographic Details
Main Authors: Arun Upadhyay, Deepak Chhangani, Nalini R. Rao, Julia Kofler, Robert Vassar, Diego E. Rincon-Limas, Jeffrey N. Savas
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Amyloid
Drosophila
Fibril purification
Proteomics
Amyloidome
Online Access:https://doi.org/10.1186/s13024-023-00654-z

Internet

https://doi.org/10.1186/s13024-023-00654-z

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