A novel roadmap connecting the 1H-MRS total choline resonance to all hallmarks of cancer following targeted therapy
Abstract This review describes a cellular adaptive stress signalling roadmap connecting the 1H magnetic resonance spectroscopy (MRS) total choline peak at 3.2 ppm (tCho) to cancer response after targeted therapy (TT). Recent research on cell signalling, tCho metabolism, and TT of cancer has been ret...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-01-01
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| Series: | European Radiology Experimental |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41747-020-00192-z |
| _version_ | 1828242036295204864 |
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| author | Egidio Iorio Franca Podo Martin O. Leach Jason Koutcher Francis G. Blankenberg Joseph F. Norfray |
| author_facet | Egidio Iorio Franca Podo Martin O. Leach Jason Koutcher Francis G. Blankenberg Joseph F. Norfray |
| author_sort | Egidio Iorio |
| collection | DOAJ |
| description | Abstract This review describes a cellular adaptive stress signalling roadmap connecting the 1H magnetic resonance spectroscopy (MRS) total choline peak at 3.2 ppm (tCho) to cancer response after targeted therapy (TT). Recent research on cell signalling, tCho metabolism, and TT of cancer has been retrospectively re-examined. Signalling research describes how the unfolded protein response (UPR), a major stress signalling network, transduces, regulates, and rewires the total membrane turnover in different cancer hallmarks after a TT stress. In particular, the UPR signalling maintains or increases total membrane turnover in all pro-survival hallmarks, whilst dramatically decreases turnover during apoptosis, a pro-death hallmark. Recent research depicts the TT-induced stress as a crucial event responsible for interrupting UPR pro-survival pathways, leading to an UPR-mediated cell death. The 1H-MRS tCho resonance represents the total mobile precursors and products during the enzymatic modification of phosphatidylcholine membrane abundance. The tCho profile represents a biomarker that noninvasively monitors TT-induced enzymatic changes in total membrane turnover in a wide variety of existing and new anticancer treatments targeting specific layers of the UPR signalling network. Our overview strongly suggests further evaluating and validating the 1H-MRS tCho peak as a powerful noninvasive imaging biomarker of cancer response in TT clinical trials. |
| first_indexed | 2024-04-12T22:08:40Z |
| format | Article |
| id | doaj.art-7eab32bd967a475aa537574c96e0a0eb |
| institution | Directory Open Access Journal |
| issn | 2509-9280 |
| language | English |
| last_indexed | 2024-04-12T22:08:40Z |
| publishDate | 2021-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | European Radiology Experimental |
| spelling | doaj.art-7eab32bd967a475aa537574c96e0a0eb2022-12-22T03:14:50ZengSpringerOpenEuropean Radiology Experimental2509-92802021-01-015111410.1186/s41747-020-00192-zA novel roadmap connecting the 1H-MRS total choline resonance to all hallmarks of cancer following targeted therapyEgidio Iorio0Franca Podo1Martin O. Leach2Jason Koutcher3Francis G. Blankenberg4Joseph F. Norfray5High Resolution NMR Unit-Core Facilities, Istituto Superiore di Sanità, Viale Regina ElenaHigh Resolution NMR Unit-Core Facilities, Istituto Superiore di Sanità, Viale Regina ElenaMRI Unit, Royal Marsden HospitalDepartment of Medicine, Memorial Sloan Kettering Cancer CenterStanford University/MIPSEmeritus, Chicago Northside MRI CenterAbstract This review describes a cellular adaptive stress signalling roadmap connecting the 1H magnetic resonance spectroscopy (MRS) total choline peak at 3.2 ppm (tCho) to cancer response after targeted therapy (TT). Recent research on cell signalling, tCho metabolism, and TT of cancer has been retrospectively re-examined. Signalling research describes how the unfolded protein response (UPR), a major stress signalling network, transduces, regulates, and rewires the total membrane turnover in different cancer hallmarks after a TT stress. In particular, the UPR signalling maintains or increases total membrane turnover in all pro-survival hallmarks, whilst dramatically decreases turnover during apoptosis, a pro-death hallmark. Recent research depicts the TT-induced stress as a crucial event responsible for interrupting UPR pro-survival pathways, leading to an UPR-mediated cell death. The 1H-MRS tCho resonance represents the total mobile precursors and products during the enzymatic modification of phosphatidylcholine membrane abundance. The tCho profile represents a biomarker that noninvasively monitors TT-induced enzymatic changes in total membrane turnover in a wide variety of existing and new anticancer treatments targeting specific layers of the UPR signalling network. Our overview strongly suggests further evaluating and validating the 1H-MRS tCho peak as a powerful noninvasive imaging biomarker of cancer response in TT clinical trials.https://doi.org/10.1186/s41747-020-00192-zBiomarkersCholineMagnetic resonance spectroscopyNeoplasmsUnfolded protein response |
| spellingShingle | Egidio Iorio Franca Podo Martin O. Leach Jason Koutcher Francis G. Blankenberg Joseph F. Norfray A novel roadmap connecting the 1H-MRS total choline resonance to all hallmarks of cancer following targeted therapy European Radiology Experimental Biomarkers Choline Magnetic resonance spectroscopy Neoplasms Unfolded protein response |
| title | A novel roadmap connecting the 1H-MRS total choline resonance to all hallmarks of cancer following targeted therapy |
| title_full | A novel roadmap connecting the 1H-MRS total choline resonance to all hallmarks of cancer following targeted therapy |
| title_fullStr | A novel roadmap connecting the 1H-MRS total choline resonance to all hallmarks of cancer following targeted therapy |
| title_full_unstemmed | A novel roadmap connecting the 1H-MRS total choline resonance to all hallmarks of cancer following targeted therapy |
| title_short | A novel roadmap connecting the 1H-MRS total choline resonance to all hallmarks of cancer following targeted therapy |
| title_sort | novel roadmap connecting the 1h mrs total choline resonance to all hallmarks of cancer following targeted therapy |
| topic | Biomarkers Choline Magnetic resonance spectroscopy Neoplasms Unfolded protein response |
| url | https://doi.org/10.1186/s41747-020-00192-z |
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