Reciprocal regulation of NRF2 by autophagy and ubiquitin–proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles

Reciprocal regulation of NRF2 by autophagy and ubiquitin–proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles

Highlights 1. CuONPs exposure activates NRF2 signaling in vascular endothelial cells and mouse thoracic aorta. 2. KEAP1 is dispensable for NRF2 activation in CuONPs-treated vascular endothelial cells. 3. CuONPs-induced autophagy facilitates NRF2 activation in vascular endothelial cells and mouse tho...

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Bibliographic Details
Main Authors: Na Li, Hang Du, Lejiao Mao, Ge Xu, Mengling Zhang, Yinzhen Fan, Xiaomei Dong, Lijun Zheng, Bin Wang, Xia Qin, Xuejun Jiang, Chengzhi Chen, Zhen Zou, Jun Zhang
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Nanobiotechnology
Subjects:
CuONPs
Vascular injury
NRF2
Autophagy
Ubiquitin–proteasome system
Online Access:https://doi.org/10.1186/s12951-022-01486-7

Internet

https://doi.org/10.1186/s12951-022-01486-7

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