Reciprocal regulation of NRF2 by autophagy and ubiquitin–proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles
Highlights 1. CuONPs exposure activates NRF2 signaling in vascular endothelial cells and mouse thoracic aorta. 2. KEAP1 is dispensable for NRF2 activation in CuONPs-treated vascular endothelial cells. 3. CuONPs-induced autophagy facilitates NRF2 activation in vascular endothelial cells and mouse tho...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-06-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01486-7 |
| _version_ | 1811278434912960512 |
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| author | Na Li Hang Du Lejiao Mao Ge Xu Mengling Zhang Yinzhen Fan Xiaomei Dong Lijun Zheng Bin Wang Xia Qin Xuejun Jiang Chengzhi Chen Zhen Zou Jun Zhang |
| author_facet | Na Li Hang Du Lejiao Mao Ge Xu Mengling Zhang Yinzhen Fan Xiaomei Dong Lijun Zheng Bin Wang Xia Qin Xuejun Jiang Chengzhi Chen Zhen Zou Jun Zhang |
| author_sort | Na Li |
| collection | DOAJ |
| description | Highlights 1. CuONPs exposure activates NRF2 signaling in vascular endothelial cells and mouse thoracic aorta. 2. KEAP1 is dispensable for NRF2 activation in CuONPs-treated vascular endothelial cells. 3. CuONPs-induced autophagy facilitates NRF2 activation in vascular endothelial cells and mouse thoracic aorta. 4. Autophagy and ubiquitin–proteasome reciprocally regulate NRF2 activation in CuONPs-treated vascular endothelial cells and mouse thoracic aorta. |
| first_indexed | 2024-04-13T00:35:48Z |
| format | Article |
| id | doaj.art-7eb5ce647b2e444cb52a286a2e4cead5 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-13T00:35:48Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-7eb5ce647b2e444cb52a286a2e4cead52022-12-22T03:10:20ZengBMCJournal of Nanobiotechnology1477-31552022-06-0120111710.1186/s12951-022-01486-7Reciprocal regulation of NRF2 by autophagy and ubiquitin–proteasome modulates vascular endothelial injury induced by copper oxide nanoparticlesNa Li0Hang Du1Lejiao Mao2Ge Xu3Mengling Zhang4Yinzhen Fan5Xiaomei Dong6Lijun Zheng7Bin Wang8Xia Qin9Xuejun Jiang10Chengzhi Chen11Zhen Zou12Jun Zhang13Molecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical UniversityChongqing Prevention and Treatment Center for Occupational Diseases, Chongqing Key Laboratory of Prevention and Treatment for Occupational Diseases and PoisoningMolecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical UniversityMolecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical UniversityCollege of Pharmacy, Chongqing Medical UniversityMolecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical UniversityMolecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical UniversityMolecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical UniversityMolecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical UniversityDepartment of Pharmacy, The First Affiliated Hospital of Chongqing Medical UniversityCenter of Experimental Teaching for Public Health, Experimental Teaching and Management Center, Chongqing Medical UniversityDepartment of Occupational and Environmental Health, School of Public Health, Chongqing Medical UniversityMolecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical UniversityMolecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical UniversityHighlights 1. CuONPs exposure activates NRF2 signaling in vascular endothelial cells and mouse thoracic aorta. 2. KEAP1 is dispensable for NRF2 activation in CuONPs-treated vascular endothelial cells. 3. CuONPs-induced autophagy facilitates NRF2 activation in vascular endothelial cells and mouse thoracic aorta. 4. Autophagy and ubiquitin–proteasome reciprocally regulate NRF2 activation in CuONPs-treated vascular endothelial cells and mouse thoracic aorta.https://doi.org/10.1186/s12951-022-01486-7CuONPsVascular injuryNRF2AutophagyUbiquitin–proteasome system |
| spellingShingle | Na Li Hang Du Lejiao Mao Ge Xu Mengling Zhang Yinzhen Fan Xiaomei Dong Lijun Zheng Bin Wang Xia Qin Xuejun Jiang Chengzhi Chen Zhen Zou Jun Zhang Reciprocal regulation of NRF2 by autophagy and ubiquitin–proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles Journal of Nanobiotechnology CuONPs Vascular injury NRF2 Autophagy Ubiquitin–proteasome system |
| title | Reciprocal regulation of NRF2 by autophagy and ubiquitin–proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles |
| title_full | Reciprocal regulation of NRF2 by autophagy and ubiquitin–proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles |
| title_fullStr | Reciprocal regulation of NRF2 by autophagy and ubiquitin–proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles |
| title_full_unstemmed | Reciprocal regulation of NRF2 by autophagy and ubiquitin–proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles |
| title_short | Reciprocal regulation of NRF2 by autophagy and ubiquitin–proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles |
| title_sort | reciprocal regulation of nrf2 by autophagy and ubiquitin proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles |
| topic | CuONPs Vascular injury NRF2 Autophagy Ubiquitin–proteasome system |
| url | https://doi.org/10.1186/s12951-022-01486-7 |
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