Custom G4 Microarrays Reveal Selective G-Quadruplex Recognition of Small Molecule BMVC: A Large-Scale Assessment of Ligand Binding Selectivity

Custom G4 Microarrays Reveal Selective G-Quadruplex Recognition of Small Molecule BMVC: A Large-Scale Assessment of Ligand Binding Selectivity

G-quadruplexes (G4) are considered new drug targets for human diseases such as cancer. More than 10,000 G4s have been discovered in human chromatin, posing challenges for assessing the selectivity of a G4-interactive ligand. 3,6-bis(1-Methyl-4-vinylpyridinium) carbazole diiodide (BMVC) is the first...

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Bibliographic Details
Main Authors: Guanhui Wu, Desiree Tillo, Sreejana Ray, Ta-Chau Chang, John S. Schneekloth, Charles Vinson, Danzhou Yang
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
G-quadruplex
G4
microarray
ligand selectivity
BMVC
MYC
Online Access:https://www.mdpi.com/1420-3049/25/15/3465

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https://www.mdpi.com/1420-3049/25/15/3465

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