Hypermethylation of the G protein‐coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBPα, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells

Hypermethylation of the G protein‐coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBPα, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells

We previously reported that the expression of G protein‐coupled receptor kinase 6 (GRK6) is significantly downregulated in lung adenocarcinoma (LADC) tissues, and low expression levels of GRK6 are correlated with poor survival prognosis. However, the specific regulatory mechanisms and functions of G...

Full description

Bibliographic Details
Main Authors: Sumei Yao, Dandan Wu, Jinliang Chen, Peng Wang, Xuedong Lv, Jianan Huang
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:FEBS Open Bio
Subjects:
C/EBPα
DNA methylation
epigenetic regulation
GRK6
lung adenocarcinoma
Online Access:https://doi.org/10.1002/2211-5463.12606

Internet

https://doi.org/10.1002/2211-5463.12606

Similar Items