The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the <i>Aγ-Globin</i> Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers

The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the <i>Aγ-Globin</i> Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers

The human homologue of mouse Ly-1 antibody reactive clone protein (LYAR) is a putative novel regulator of <i>γ-globin</i> gene transcription. The LYAR DNA-binding motif (5′-GGTTAT-3′) is located within the 5′-UTR of the <i>Aγ-globin</i> gene. The LYAR rs368698783 (G>A) pol...

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Bibliographic Details
Main Authors: Cristina Zuccato, Lucia Carmela Cosenza, Matteo Zurlo, Giulia Breveglieri, Nicoletta Bianchi, Ilaria Lampronti, Jessica Gasparello, Chiara Scapoli, Monica Borgatti, Alessia Finotti, Roberto Gambari
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
β-thalassemia
fetal hemoglobin
rs368698783
LYAR
Online Access:https://www.mdpi.com/1422-0067/24/1/776

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https://www.mdpi.com/1422-0067/24/1/776

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