Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains

Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains

Abstract Background Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide range of debilitating symptoms. Several aspects of its multifactorial complexity are still unknown, and some are accepted to be an early developmental deficiency with a more specifically neurodevelopment...

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Bibliographic Details
Main Authors: Juliana Minardi Nascimento, Verônica M. Saia-Cereda, Giuliana S. Zuccoli, Guilherme Reis-de-Oliveira, Victor Corasolla Carregari, Bradley J. Smith, Stevens K. Rehen, Daniel Martins-de-Souza
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Cell & Bioscience
Subjects:
Neuroproteomics
Schizophrenia
Brain organoids
Neural cells
Human pluripotent stem cells
Online Access:https://doi.org/10.1186/s13578-022-00928-x

Internet

https://doi.org/10.1186/s13578-022-00928-x

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