Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases

Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases

Members of the Flaviviridae family constitute a severe risk to human health. Whilst effective drugs have been developed against the hepacivirus HCV, no antiviral therapy is currently available for any other viruses, including the flaviviruses dengue (DENV), West Nile and Zika viruses. The RNA-depend...

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Bibliographic Details
Main Authors: Federica Riccio, Sandeep K. Talapatra, Sally Oxenford, Richard Angell, Michela Mazzon, Frank Kozielski
Format: Article
Language:English
Published: The Company of Biologists 2019-01-01
Series:Biology Open
Subjects:
Dengue virus
Crystallization screen
RNA-dependent RNA polymerase
Flavivirus
Antiviral drug discovery
Online Access:http://bio.biologists.org/content/8/1/bio037663

Internet

http://bio.biologists.org/content/8/1/bio037663

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