RAGE inhibition blunts insulin-induced oncogenic signals in breast cancer

RAGE inhibition blunts insulin-induced oncogenic signals in breast cancer

Abstract The receptor for advanced glycation end products (RAGE) is implicated in diabetes and obesity complications, as well as in breast cancer (BC). Herein, we evaluated whether RAGE contributes to the oncogenic actions of Insulin, which plays a key role in BC progression particularly in obese an...

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Bibliographic Details
Main Authors: M. G. Muoio, M. Pellegrino, V. Rapicavoli, M. Talia, G. Scavo, V. Sergi, V. Vella, S. Pettinato, M. G. Galasso, R. Lappano, D. Scordamaglia, F. Cirillo, A. Pulvirenti, D. C. Rigiracciolo, M. Maggiolini, A. Belfiore, E. M. De Francesco
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Breast Cancer Research
Subjects:
Insulin
Insulin receptor
Breast cancer
RAGE
CAFs
Online Access:https://doi.org/10.1186/s13058-023-01686-5

Internet

https://doi.org/10.1186/s13058-023-01686-5

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