CPSF6 defines a conserved capsid interface that modulates HIV-1 replication.
The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in CA sequence alters HIV-1 infectivity and escape from host restriction factors. However, apart from the Cyclophilin A-binding loop, CA has no known interfaces with which to interact with cellular cofactors. He...
| Главные авторы: | , , , , , , , , |
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| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
Public Library of Science (PLoS)
2012-01-01
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| Серии: | PLoS Pathogens |
| Online-ссылка: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002896&type=printable |