Interleukin-4 from curcumin-activated OECs emerges as a central modulator for increasing M2 polarization of microglia/macrophage in OEC anti-inflammatory activity for functional repair of spinal cord injury

Interleukin-4 from curcumin-activated OECs emerges as a central modulator for increasing M2 polarization of microglia/macrophage in OEC anti-inflammatory activity for functional repair of spinal cord injury

Abstract Microglia/macrophages are major contributors to neuroinflammation in the central nervous system (CNS) injury and exhibit either pro- or anti-inflammatory phenotypes in response to specific microenvironmental signals. Our latest in vivo and in vitro studies demonstrated that curcumin-treated...

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Bibliographic Details
Main Authors: Jianbin Guo, Xiangwen Tang, Peng Deng, Hao Hui, Bo Chen, Jing An, Gaorong Zhang, Kuohao Shi, Jinchao Wang, Yuqing He, Dingjun Hao, Hao Yang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Cell Communication and Signaling
Subjects:
Activated olfactory ensheathing cells
Interleukin-4
Microglia/macrophage polarization
Neuroinflammation
JAK1/STAT1/STAT3/STAT6
Online Access:https://doi.org/10.1186/s12964-024-01539-4

Internet

https://doi.org/10.1186/s12964-024-01539-4

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