High urea induces depression and LTP impairment through mTOR signalling suppression caused by carbamylation

High urea induces depression and LTP impairment through mTOR signalling suppression caused by carbamylation

Background: Urea, the end product of protein metabolism, has been considered to have negligible toxicity for a long time. Our previous study showed a depression phenotype in urea transporter (UT) B knockout mice, which suggests that abnormal urea metabolism may cause depression. The purpose of this...

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Bibliographic Details
Main Authors: Hongkai Wang, Boyue Huang, Weiling Wang, Jinfang Li, Yi Chen, Trevor Flynn, Meng Zhao, Zhiming Zhou, Xiaojing Lin, Yinan Zhang, Mengmeng Xu, Keqiong Li, Kuan Tian, Dezhi Yuan, Peng Zhou, Ling Hu, Dandan Zhong, Shuai Zhu, Jing Li, Dilong Chen, Kejian Wang, Jianhui Liang, Qihua He, Jianbin Sun, Jie Shi, Li Yan, Jeff M Sands, Zhengwei Xie, Xuemei Lian, Duan Xu, Jianhua Ran, Baoxue Yang
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419306371

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http://www.sciencedirect.com/science/article/pii/S2352396419306371

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