Differential activation of catalase expression and activity by PPAR agonists: Implications for astrocyte protection in anti-glioma therapy

Differential activation of catalase expression and activity by PPAR agonists: Implications for astrocyte protection in anti-glioma therapy

Glioma survival is dismal, in part, due to an imbalance in antioxidant expression and activity. Peroxisome proliferator-activated receptor (PPAR) agonists have antineoplastic properties which present new redox-dependent targets for glioma anticancer therapies. Herein, we demonstrate that treatment o...

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Bibliographic Details
Main Authors: Nicholas K.H. Khoo, Sachin Hebbar, Weiling Zhao, Steven A. Moore, Frederick E. Domann, Mike E. Robbins
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Redox Biology
Subjects:
Catalase
Primary rat astrocytes
C6 glioma cells
PPAR agonists
PPARγ-dominant negative
Transfection
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231712000213

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http://www.sciencedirect.com/science/article/pii/S2213231712000213

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