p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway

p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway

Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory pro-cesses. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (mTORC1). How-ever, additional pathways that m...

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Bibliographic Details
Main Authors: Clarissa Braun, Karl Katholnig, Christopher Kaltenecker, Monika Linke, Nyamdelger Sukhbaatar, Markus Hengstschläger, Thomas Weichhart
Format: Article
Language:English
Published: Shared Science Publishers OG 2021-11-01
Series:Cell Stress
Subjects:
macrophages
cancer
rapamycin
mk2
pdcd4
p38
mtorc1
tsc1
tsc2
Online Access:http://www.cell-stress.com/researcharticles/2021a-braun-cell-stress/

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http://www.cell-stress.com/researcharticles/2021a-braun-cell-stress/

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