Solubility of lamotrigine in age-specific biorelevant media that simulated the fasted- and fed-conditions of the gastric and intestinal environments in pediatrics and adults: implications for traditional, re-formulated, modified, and new oral formulations

Solubility of lamotrigine in age-specific biorelevant media that simulated the fasted- and fed-conditions of the gastric and intestinal environments in pediatrics and adults: implications for traditional, re-formulated, modified, and new oral formulations

Abstract Background Lamotrigine is an effective antiseizure medication that can be used in the management of focal and generalized epilepsies in pediatric patients. This study was conducted to quantify and compare the solubility of lamotrigine in age-specific biorelevant media that simulated the fas...

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Bibliographic Details
Main Authors: Ramzi Shawahna, Hala Saba’aneh, Amal Daraghmeh, Yara Qassarwi, Valentina Franco, Xavier Declèves
Format: Article
Language:English
Published: BMC 2023-09-01
Series:BMC Biotechnology
Subjects:
Lamotrigine
Pediatric
Solubility
Dosage form performance
Biopharmaceutics
Biorelevant
Online Access:https://doi.org/10.1186/s12896-023-00809-2

Internet

https://doi.org/10.1186/s12896-023-00809-2

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