Oxidative stress and inflammation distinctly drive molecular mechanisms of diastolic dysfunction and remodeling in female and male heart failure with preserved ejection fraction rats

Oxidative stress and inflammation distinctly drive molecular mechanisms of diastolic dysfunction and remodeling in female and male heart failure with preserved ejection fraction rats

Heart failure with preserved ejection fraction (HFpEF) is a complex cardiovascular insufficiency syndrome presenting with an ejection fraction (EF) of greater than 50% along with different proinflammatory and metabolic co-morbidities. Despite previous work provided key insights into our understandin...

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Bibliographic Details
Main Authors: Saltanat Zhazykbayeva, Roua Hassoun, Melissa Herwig, Heidi Budde, Árpád Kovács, Hans Georg Mannherz, Ibrahim El-Battrawy, Attila Tóth, Wolfgang E. Schmidt, Andreas Mügge, Nazha Hamdani
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
diastolic dysfunction
sex differences
mechanisms
oxidative stress
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1157398/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2023.1157398/full

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