TNFα secreted by glioma associated macrophages promotes endothelial activation and resistance against anti-angiogenic therapy

TNFα secreted by glioma associated macrophages promotes endothelial activation and resistance against anti-angiogenic therapy

Abstract One of the most prominent features of glioblastoma (GBM) is hyper-vascularization. Bone marrow-derived macrophages are actively recruited to the tumor and referred to as glioma-associated macrophages (GAMs) which are thought to provide a critical role in tumor neo-vascularization. However,...

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Bibliographic Details
Main Authors: Qingxia Wei, Olivia Singh, Can Ekinci, Jaspreet Gill, Mira Li, Yasin Mamatjan, Shirin Karimi, Severa Bunda, Sheila Mansouri, Kenneth Aldape, Gelareh Zadeh
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Acta Neuropathologica Communications
Subjects:
Glioblastoma
Glioma-associated macrophages
Endothelial cells activation
TNFα
Anti-angiogenic therapy
Online Access:https://doi.org/10.1186/s40478-021-01163-0

Internet

https://doi.org/10.1186/s40478-021-01163-0

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