Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy

Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy

Abstract Background Active targeting by surface-modified nanoplatforms enables a more precise and elevated accumulation of nanoparticles within the tumor, thereby enhancing drug delivery and efficacy for a successful cancer treatment. However, surface functionalization involves complex procedures th...

Full description

Bibliographic Details
Main Authors: José L. Blaya-Cánovas, Carmen Griñán-Lisón, Isabel Blancas, Juan A. Marchal, César Ramírez-Tortosa, Araceli López-Tejada, Karim Benabdellah, Marina Cortijo-Gutiérrez, M. Victoria Cano-Cortés, Pablo Graván, Saúl A. Navarro-Marchal, Jaime Gómez-Morales, Violeta Delgado-Almenta, Jesús Calahorra, María Agudo-Lera, Amaia Sagarzazu, Carlos J. Rodríguez-González, Tania Gallart-Aragón, Christina Eich, Rosario M. Sánchez-Martín, Sergio Granados-Principal
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Molecular Cancer
Subjects:
Biomimetic nanoparticles
Immune evasion
PD1
PDL1
T-cell exhaustion
Immune checkpoint
Online Access:https://doi.org/10.1186/s12943-024-01997-x

Internet

https://doi.org/10.1186/s12943-024-01997-x

Similar Items