Co-Amorphous Screening for the Solubility Enhancement of Poorly Water-Soluble Mirabegron and Investigation of Their Intermolecular Interactions and Dissolution Behaviors

Co-Amorphous Screening for the Solubility Enhancement of Poorly Water-Soluble Mirabegron and Investigation of Their Intermolecular Interactions and Dissolution Behaviors

In the present study, the screening of Mirabegron (MBR) co-amorphous was performed to produce water-soluble and thermodynamically stable MBR co-amorphous with the purpose of overcoming the water solubility problem of MBR. MBR is Biopharmaceutics Classification System (BCS) class II drug used for the...

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Bibliographic Details
Main Authors: Ji-Hun An, Changjin Lim, Alice Nguvoko Kiyonga, In Hwa Chung, In Kyu Lee, Kilwoong Mo, Minho Park, Wonno Youn, Won Rak Choi, Young-Ger Suh, Kiwon Jung
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Pharmaceutics
Subjects:
mirabegron
co-amorphous
active pharmaceutical ingredient
aqueous solubility
ionic interaction
Online Access:http://www.mdpi.com/1999-4923/10/3/149

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http://www.mdpi.com/1999-4923/10/3/149

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