Case report: Granzyme-B expression by T- and B- cells during severe AQP4-positive Neuromyelitis Optica spectrum disorder with fatal venous thromboembolism outcome

Case report: Granzyme-B expression by T- and B- cells during severe AQP4-positive Neuromyelitis Optica spectrum disorder with fatal venous thromboembolism outcome

BackgroundThe expression of serine protease granzyme-B (GzmB) by circulating CD8+ T lymphocytes has been recently suggested as a biomarker for poor immunotherapy response and severe disability in patients with Neuromyelitis Optica spectrum disorders (NMOSD). In parallel, venous thromboembolism (VTE)...

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Bibliographic Details
Main Authors: Vinícius Oliveira Boldrini, Mariana Rabelo Brito, Raphael Patrício Silva Quintiliano, Lucas Scárdua Silva, Clarissa Lin Yasuda, Fernando Cendes, Alessandro Santos Farias, Alfredo Damasceno
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Neurology
Subjects:
Devic's syndrome
deep vein thrombosis (DVT)
pulmonary thromboembolism
T lymphocytes
B cells
granzyme-B
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1208977/full

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https://www.frontiersin.org/articles/10.3389/fneur.2023.1208977/full

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