A novel AML1-ETO/FTO positive feedback loop promotes leukemogenesis and Ara-C resistance via stabilizing IGFBP2 in t(8;21) acute myeloid leukemia

A novel AML1-ETO/FTO positive feedback loop promotes leukemogenesis and Ara-C resistance via stabilizing IGFBP2 in t(8;21) acute myeloid leukemia

Abstract Background t(8;21)(q22;q22) is one of the most frequent chromosomal abnormalities in acute myeloid leukemia (AML), leading to the generation of the fusion protein AML1-ETO. Despite t(8;21) AML being considered as a subtype with a favorable prognosis, approximately 30–50% of patients experie...

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Bibliographic Details
Main Authors: Wei Zhou, Siying Li, Hong Wang, Jingfeng Zhou, Shuyi Li, Guofeng Chen, Wei Guan, Xianli Fu, Clara Nervi, Li Yu, Yonghui Li
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Experimental Hematology & Oncology
Subjects:
t(8;21) acute myeloid leukemia
AML1-ETO
N6-methyladenosine
FTO
Ara-C resistance
Online Access:https://doi.org/10.1186/s40164-024-00480-z

Internet

https://doi.org/10.1186/s40164-024-00480-z

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