The TRPM4 channel inhibitor 9-phenanthrol alleviates cerebral edema after traumatic brain injury in rats

The TRPM4 channel inhibitor 9-phenanthrol alleviates cerebral edema after traumatic brain injury in rats

Cerebral edema (CE) exerts an important effect on brain injury after traumatic brain injury (TBI). Upregulation of transient receptor potential melastatin 4 (TRPM4) in vascular endothelial cells (ECs) results in damage to capillaries and the blood-brain barrier (BBB), which is critical for the devel...

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Bibliographic Details
Main Authors: Ping Ma, Ning Huang, Jun Tang, Zunjie Zhou, Jing Xu, Yi Chen, Maoxin Zhang, Qin Huang, Yuan Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
traumatic brain injury
cerebral edema
9-phenanthrol
TRPM4
MMP-9
PI3K/AKT/NF-kB signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1098228/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1098228/full

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