Excitability, synaptic balance, and addiction: The homeostatic dynamics of ionotropic glutamatergic receptors in VTA after cocaine exposure

Excitability, synaptic balance, and addiction: The homeostatic dynamics of ionotropic glutamatergic receptors in VTA after cocaine exposure

Abstract Glutamatergic AMPA and NMDA receptors in the ventral tegmental area (VTA) are central for cocaine first exposure and posterior craving maintenance. However, the exact rules that coordinate the synaptic dynamics of these receptors in dopaminergic VTA neurons and behavioral outcomes are poorl...

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Bibliographic Details
Main Authors: Thiago C. Moulin, Helgi B. Schiöth
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Behavioral and Brain Functions
Subjects:
Drug dependence
Withdrawal
Homeostatic plasticity
Synaptic scaling
Dopamine
Online Access:http://link.springer.com/article/10.1186/s12993-020-00168-4

Internet

http://link.springer.com/article/10.1186/s12993-020-00168-4

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