Biomarkers beyond BRCA: promising combinatorial treatment strategies in overcoming resistance to PARP inhibitors

Biomarkers beyond BRCA: promising combinatorial treatment strategies in overcoming resistance to PARP inhibitors

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) exploit the concept of synthetic lethality and offer great promise in the treatment of tumors with deficiencies in homologous recombination (HR) repair. PARPi exert antitumor activity by blocking Poly(ADP-ribosyl)ation (PARylation) and...

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Bibliographic Details
Main Authors: Yu-Yi Chu, Clinton Yam, Hirohito Yamaguchi, Mien-Chie Hung
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Biomedical Science
Subjects:
PARP inhibitor
Resistance to PARP inhibitor
Biomarkers
PARPi-based combination strategies
Marker-guided effective therapy (Mget)
Online Access:https://doi.org/10.1186/s12929-022-00870-7

Internet

https://doi.org/10.1186/s12929-022-00870-7

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