Impact of TNF-α Gene Polymorphisms on Pancreatic and Non-Small Cell Lung Cancer-Induced Cachexia in Adult Egyptian Patients: A Focus on Pathogenic Trajectories

Impact of TNF-α Gene Polymorphisms on Pancreatic and Non-Small Cell Lung Cancer-Induced Cachexia in Adult Egyptian Patients: A Focus on Pathogenic Trajectories

BackgroundCachexia is a frequent syndrome in pancreatic and non-small cell lung (NSCL) cancer patients. The storm of cancer-induced inflammatory cytokines, in particular TNF-α, is a crucial pathogenic mechanism. Among the molecular alterations accused of cancer-induced cachexia, TNF-α 308 G/A (rs180...

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Bibliographic Details
Main Authors: Rana Yehia, Mona Schaalan, Dalaal M. Abdallah, Amr S. Saad, Neven Sarhan, Samira Saleh
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Oncology
Subjects:
pancreatic and NSCL cancer
cachexia
single-nucleotide polymorphism
TNF-α gene
miR-155
SOCS1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.783231/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.783231/full

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