Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation

Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation

Objective: There is strong evidence that mitochondrial DNA mutations and mitochondrial dysfunction play a role in diabetes pathogenesis. The homozygous knock-in mtDNA mutator mouse is a model of premature aging due to the accumulation of mitochondrial DNA mutations. We used this mouse model to inves...

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Bibliographic Details
Main Authors: Xuefei Yu, Catherine Arden, Rolando Berlinguer-Palmini, Chun Chen, Carla Bradshaw, Anna LM Smith, Julia Whitehall, Michael White, Scott Anderson, Nicole Kattner, James Shaw, Doug Turnbull, Laura C Greaves, Mark Walker
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Metabolism
Subjects:
Mitochondria
mtDNA
mtDNA mutator mice
Pancreatic islets
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822000588

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http://www.sciencedirect.com/science/article/pii/S2212877822000588

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