Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells

ABSTRACT Chronic bacterial infections are difficult to eradicate, though they are caused primarily by drug-susceptible pathogens. Antibiotic-tolerant persisters largely account for this paradox. In spite of their significance in the recalcitrance of chronic infections, the mechanism of persister for...

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Bibliographic Details
Main Authors: Eliza A. Zalis, Austin S. Nuxoll, Sylvie Manuse, Geremy Clair, Lauren C. Radlinski, Brian P. Conlon, Joshua Adkins, Kim Lewis
Format: Article
Language:English
Published: American Society for Microbiology 2019-10-01
Series:mBio
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mBio.01930-19