Integration of ER protein quality-control mechanisms defines β cell function and ER architecture

Integration of ER protein quality-control mechanisms defines β cell function and ER architecture

Three principal ER quality-control mechanisms, namely, the unfolded protein response, ER-associated degradation (ERAD), and ER-phagy are each important for the maintenance of ER homeostasis, yet how they are integrated to regulate ER homeostasis and organellar architecture in vivo is largely unclear...

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Bibliographic Details
Main Authors: Neha Shrestha, Mauricio Torres, Jason Zhang, You Lu, Leena Haataja, Rachel B. Reinert, Jeffrey Knupp, Yu-Jie Chen, Allen H. Hunter, Gunes Parlakgul, Ana Paula Arruda, Billy Tsai, Peter Arvan, Ling Qi
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-02-01
Series:The Journal of Clinical Investigation
Subjects:
Cell biology
Metabolism
Online Access:https://doi.org/10.1172/JCI163584

Internet

https://doi.org/10.1172/JCI163584

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