HPV16 E6/E7 upregulate hTERC mRNA and gene amplification levels by relieving the effect of LKB1 on Sp1 phosphorylation in lung cancer cells

Background: There is an immediate need for research on the mechanism underlying telomerase activation and overexpression. Materials & Methods: A total of 174 patients with lung cancer ( n  = 106) and benign lung disease ( n  = 68) were recruited for the current study. The mRNA expression levels...

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Bibliographic Details
Main Authors: Jing-Hua Yang, Ming-Zhe Wu, Xu-Bo Wang, Shiyu Wang, Xue-Shan Qiu, En-Hua Wang, Guang-Ping Wu
Format: Article
Language:English
Published: SAGE Publishing 2020-05-01
Series:Therapeutic Advances in Medical Oncology
Online Access:https://doi.org/10.1177/1758835920917562