Establishing the pig as a large animal model for vaccine development against human cancer

Establishing the pig as a large animal model for vaccine development against human cancer

Immunotherapy has increased overall survival of metastatic cancer patients, and cancer antigens are promising vaccine targets. To fulfill the promise, appropriate tailoring of the vaccine formulations to mount in vivo cytotoxic T cell (CTL) responses towards co-delivered cancer antigens is essential...

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Bibliographic Details
Main Authors: Nana Haahr Overgaard, Thomas Mørch Frøsig, Simon eWelner, Michael eRasmussen, Mette eIlsøe, Maria Rathmann Sørensen, Mads Hald Andersen, Søren eBuus, Gregers eJungersen
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Genetics
Subjects:
Adjuvants, Immunologic
Cancer Vaccines
animal model
Cytotoxic T Cells
immune therapy
peptide-MHC stability
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00286/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00286/full

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