Dissecting the cellular components of ex vivo γδ T cell expansions to optimize selection of potent cell therapy donors for neuroblastoma immunotherapy trials

Dissecting the cellular components of ex vivo γδ T cell expansions to optimize selection of potent cell therapy donors for neuroblastoma immunotherapy trials

γδ T lymphocytes represent an emerging class of cellular immunotherapy with preclinical promise to treat cancer, notably neuroblastoma. The innate-like immune cell subset demonstrates inherent cytoxicity toward tumor cells independent of MHC recognition, enabling allogeneic administration of healthy...

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Bibliographic Details
Main Authors: Hunter C. Jonus, Rebecca E. Burnham, Andrew Ho, Adeiye A. Pilgrim, Jenny Shim, Christopher B. Doering, H. Trent Spencer, Kelly C. Goldsmith
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
γδ T cells
natural killer (NK) cells
neuroblastoma
dinutuximab
ADCC
adoptive cell therapy
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2057012

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2022.2057012

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