Reduced CD27−IgD− B Cells in Blood and Raised CD27−IgD− B Cells in Gut-Associated Lymphoid Tissue in Inflammatory Bowel Disease

Reduced CD27−IgD− B Cells in Blood and Raised CD27−IgD− B Cells in Gut-Associated Lymphoid Tissue in Inflammatory Bowel Disease

The intestinal mucosa in inflammatory bowel disease (IBD) contains increased frequencies of lymphocytes and a disproportionate increase in plasma cells secreting immunoglobulin (Ig)G relative to other isotypes compared to healthy controls. Despite consistent evidence of B lineage cells in the mucosa...

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Bibliographic Details
Main Authors: Chathyan Pararasa, Na Zhang, Thomas J. Tull, Ming H. A. Chong, Jacqueline H. Y. Siu, William Guesdon, Konstantia Maria Chavele, Jeremy D. Sanderson, Louise Langmead, Klaartje Kok, Jo Spencer, Anna Vossenkamper
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
memory B cells
inflammatory bowel disease
GALT
mass cytometry
biologics
ustekinumab
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00361/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00361/full

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