Chlorpromazine affects glioblastoma bioenergetics by interfering with pyruvate kinase M2

Chlorpromazine affects glioblastoma bioenergetics by interfering with pyruvate kinase M2

Abstract Glioblastoma (GBM) is the most frequent and lethal brain tumor, whose therapeutic outcome - only partially effective with current schemes - places this disease among the unmet medical needs, and effective therapeutic approaches are urgently required. In our attempts to identify repositionab...

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Bibliographic Details
Main Authors: Claudia Abbruzzese, Silvia Matteoni, Paola Matarrese, Michele Signore, Barbara Ascione, Elisabetta Iessi, Aymone Gurtner, Andrea Sacconi, Lucia Ricci-Vitiani, Roberto Pallini, Andrea Pace, Veronica Villani, Andrea Polo, Susan Costantini, Alfredo Budillon, Gennaro Ciliberto, Marco G. Paggi
Format: Article
Language:English
Published: Nature Publishing Group 2023-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06353-3

Internet

https://doi.org/10.1038/s41419-023-06353-3

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