Vaccine-induced spike- and nucleocapsid-specific cellular responses maintain potent cross-reactivity to SARS-CoV-2 Delta and Omicron variants

Vaccine-induced spike- and nucleocapsid-specific cellular responses maintain potent cross-reactivity to SARS-CoV-2 Delta and Omicron variants

Summary: Cell-mediated immunity may contribute to providing protection against SARS-CoV-2 and its variants of concern (VOC). We developed COH04S1, a synthetic multiantigen modified vaccinia Ankara (MVA)-based COVID-19 vaccine that stimulated potent spike (S) and nucleocapsid (N) antigen-specific hum...

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Bibliographic Details
Main Authors: Flavia Chiuppesi, John A. Zaia, Katelyn Faircloth, Daisy Johnson, Minh Ly, Veronica Karpinski, Corinna La Rosa, Jennifer Drake, Joan Marcia, Ann Marie Acosta, Shannon Dempsey, Randy A. Taplitz, Qiao Zhou, Yoonsuh Park, Sandra Ortega Francisco, Teodora Kaltcheva, Paul H. Frankel, Steven Rosen, Felix Wussow, Sanjeet Dadwal, Don J. Diamond
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:iScience
Subjects:
Health sciences
Immunology
Immune response
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222010173

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222010173

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