Chemo-Enzymatic Synthesis of a Multi-Useful Chiral Building Block Molecule for the Synthesis of Medicinal Compounds

Chemo-Enzymatic Synthesis of a Multi-Useful Chiral Building Block Molecule for the Synthesis of Medicinal Compounds

Optical resolution of 2-methyl-2-nitrobut-3-en-1-ol has been accomplished using a “low-temperature lipase-catalyzed transesterification” carried out at −40 °C.

Bibliographic Details
Main Authors: Toshiki Nakano, Yusuke Yagi, Motoi Kawatsura, Akio Kaminura, Mizuki Miyahara, Toshiyuki Itoh
Format: Article
Language:English
Published: MDPI AG 2011-08-01
Series:Molecules
Subjects:
nitro alcohol
quaternary chiral carbon
lipase
optically active
synthesis
Online Access:http://www.mdpi.com/1420-3049/16/8/6747/

Internet

http://www.mdpi.com/1420-3049/16/8/6747/

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