Carbonic Anhydrase IX Suppression Shifts Partial Response to Checkpoint Inhibitors into Complete Tumor Eradication: Model-Based Investigation

Carbonic Anhydrase IX Suppression Shifts Partial Response to Checkpoint Inhibitors into Complete Tumor Eradication: Model-Based Investigation

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of solid malignancies, including non-small-cell lung cancer. However, immunotherapy resistance constitutes a significant challenge. To investigate carbonic anhydrase IX (CAIX) as a driver of resistance, we built a differential equ...

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Bibliographic Details
Main Authors: Julia Grajek, Jan Poleszczuk
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
CAIX
immunotherapy
immune checkpoint inhibitors
mathematical model
combination therapy
acidosis
Online Access:https://www.mdpi.com/1422-0067/24/12/10068

Internet

https://www.mdpi.com/1422-0067/24/12/10068

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