Single residues in the outer pore of TRPV1 and TRPV3 have temperature-dependent conformations.

Thermosensation is mediated by ion channels that are highly temperature-sensitive. Several members of the family of transient receptor potential (TRP) ion channels are activated by cold or hot temperatures and have been shown to function as temperature sensors in vivo. The molecular mechanism of tem...

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Bibliographic Details
Main Authors: Sung Eun Kim, Ardem Patapoutian, Jörg Grandl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3608658?pdf=render