A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland

A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland

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Progesterone drives mammary stem and progenitor cell dynamics through paracrine mechanisms that are currently not well understood. Here, we demonstrate that CXCR4, the receptor for stromal-derived factor 1 (SDF-1; CXC12), is a crucial instructor of hormone-induced mammary stem and progenitor cell fu...

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Bibliographic Details
Main Authors: Yu-Jia Shiah, Pirashaanthy Tharmapalan, Alison E. Casey, Purna A. Joshi, Trevor D. McKee, Hartland W. Jackson, Alexander G. Beristain, Michelle A. Chan-Seng-Yue, Gary D. Bader, John P. Lydon, Paul D. Waterhouse, Paul C. Boutros, Rama Khokha
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115000326

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http://www.sciencedirect.com/science/article/pii/S2213671115000326

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