Mechanisms of receptor tyrosine kinase activation in cancer

Mechanisms of receptor tyrosine kinase activation in cancer

Abstract Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK signaling leads to an assortment of human diseases, most notably, cancers. Recent large-scale genomic studies...

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Bibliographic Details
Main Authors: Zhenfang Du, Christine M. Lovly
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Cancer
Subjects:
Receptor
Tyrosine kinase
Cancer
Mutation
Chromosomal rearrangement
Targeted therapy
Online Access:http://link.springer.com/article/10.1186/s12943-018-0782-4

Internet

http://link.springer.com/article/10.1186/s12943-018-0782-4

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