Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons

Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons

Since Src kinase inhibitors decrease brain injury produced by intracerebral hemorrhage (ICH) and thrombin is activated following ICH, this study determined whether Src kinase inhibitors decrease thrombin-induced brain injury. Thrombin injections into adult rat striatum produced focal infarction and...

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Bibliographic Details
Main Authors: Da-Zhi Liu, Xi-Yuan Cheng, Bradley P. Ander, Huichun Xu, Ryan R. Davis, Jeffrey P. Gregg, Frank R. Sharp
Format: Article
Language:English
Published: Elsevier 2008-05-01
Series:Neurobiology of Disease
Subjects:
Thrombin
Mitogenic signaling
Cell cycle
Neuronal apoptosis
Intracerebral hemorrhage
Striatum
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000089

Internet

http://www.sciencedirect.com/science/article/pii/S0969996108000089

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